Man United, meanwhile, will travel without Aaron Wan-Bissaka, Donny van de Beek and club captain Harry Maguire due to injury, but Raphael Varane is still fighting to prove he is fit enough to start alongside Lisandro Martinez at the heart of the defence.
The France international was withdrawn five minutes before half-time against Man City after sustaining an ankle injury, with Victor Lindelof waiting in the wings to deputise for him if required.
Tyrell Malacia and Jadon Sancho were both hooked at half-time against Omonia in midweek and may find themselves displaced in the starting XI by Luke Shaw and Martial at the weekend.
Everton possible starting lineup:
Pickford; Coleman, Coady, Tarkowski, Mykolenko; Onana, Gueye, Iwobi; Gordon, Maupay, Gray
Manchester United possible starting lineup:
De Gea; Dalot, Varane, Martinez, Shaw; McTominay, Eriksen; Antony, Fernandes, Rashford; Martial
We say: Everton 1-1 Manchester United